Ghom was a powerful demon in service of Azmodan. Like all demons, he fought the forces of Heaven in the Great Conflict. Ghom once devoured six angels in a single swallow - spears included.
On Sanctuary, Ghom was faced with a new enemy—humanity, specifically those serving at Bastion's Keep. He was among Azmodan's forces that laid siege to the fortress. When Azmodan's infernal siege engines breached the Keep's walls, Ghom was sent forth to spearhead the assault from within the Keep. However, a small band of heroes, under the command of Tyrael, defeated his minions on the way to the larder, and successfully dispatched the Lord of Gluttony, preventing Azmodan from achieving victory from below the keep. Before he died however, Ghom had spoiled all of the fortress's stored food. Sister Frances of the Alliance of the Dying Sun wondered how the garrison would make it through the next season.