Vitamin B6, or pyridoxine, is a very active water-soluble.
There is 6 forms of vitamin B6 one of them called Pyridoxal phosphate (PLP), PLP is the active coenzyme form and has the most importance in human metabolism.
Steroid hormones, such as estrogen and testosterone, exert their effects in the body by binding to steroid hormone receptors in the nucleus of the cell and altering gene transcription. PLP binds to steroid receptors in a manner that inhibits the binding of steroid hormones, thus decreasing their effects. The binding of PLP to steroid receptors for estrogen, progesterone, testosterone, and other steroid hormones suggests that the vitamin B6 status of an individual may have implications for diseases affected by steroid hormones, including breast cancer and prostate cancers.
Vitamin B6 must be obtained from the diet because humans cannot synthesize it.
The vitamin makes the number two spot for a very good reason: It's the only vitamin directly tied to protein intake. The more protein you eat, the more Pyridoxine you need. Of course, this, coupled with Pyridoxine's role in growth, had profound implications for bodybuilders, though it is generally not known or discussed in sports nutrition circles.
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