The Greek physician, Pedanius Dioscorides (40-90 AD) first documented the health benefits of a pinecone extract in De Materia Medica, one of the most influential herbal books in history. Dioscorides describes using extracts of pinecones to treat a variety of ailments and to apply to the skin to treat topical disorders. For much of the last century the Japanese inhabitants of the island of Kyushu have also known about the medicinal properties of a pinecone extract. They used an aqueous extract (tea) prepared from pinecones to keep healthy. More recently, pinecone extracts have been demonstrated to have immunomodulatory effects in animals, and epidemiological evidence also suggests health benefits in humans [2-7]. Proligna® pinecone extract has been awarded 11 patents internationally and is described in over 30 peer reviewed scientific studies. In a time when optimum immune function and balance is increasingly important, Proligna® pinecone extract could not be more perfect.. A healthy immune system is the body’s best defense.