Preparing my next Grad Seminar! 🔬😀. #methionine #aminoacids #histones #DNA #fluorescentproteims #FRET #mammarycells #methylation .
. Met = methionine. Why research about methionine? Because it is an essential aminoacid involved in many biological functions, including gene regulation.
. Why histones? Because histone (proteins like spools around the DNA which DNA winds) modifications such as methylation can alter the regions or the information of the DNA available for transcription.
. Is methylation bad? there is a misconception about methylation. It does silence some genes, but at the same time it opens other regions of the DNA to be transcribed...so it depends on what genes are being silencing. .
. Methionine and histone methylation? Met is the primary source for SAM (the universal methyl-donor). So the hypothesis is that methylation can be regulated by methionine availability in bovine mammary cells.