The Toltec #Mayan god Gucumatz was described as a "#serpentofwisdom" who #enlightened humankind. His #Aztec counterpart was named #Quetzalcoatl. In the Yucatan, he is called #Kukulcan.
The Hopi refer to a race of reptoids called the Sheti, or "Snake-Brothers", who live underground. The Cherokee and other Native American peoples also refer to #reptoid races.
In pre-Columbian mythology from Colombia, Bachue (the primordial woman) transformed into a big snake. She is also sometimes called the "#CelestialSnake" (Serpiente Celestial). Many users of the drug Dimethyltryptamine (the active ingredient in many South American #shamanic potions such as ayahuasca) have seen reptilian humanoids or reptilian disincarnate entities and aliens while hallucinating (Strassman 2000). Europe
Cecrops I, the legendary first King of Athens was said to have been half man, half snake. The ancient Titans and Gigantes were sometimes depicted as winged man-like beings with serpents instead of legs, for example on a fresco on a temple in Pergamum. In these images from Pergamum, some of which depict the gigantomachy, one sees the giant Klyteios with huge serpents in place of legs.
Boreas (Aquilon to the Romans) was the Greek god of the cold north wind, described by Pausanias as a winged man with serpents for legs.
The European dragon dates back to ancient depictions on various archaeological artifacts. An early instance in literature was the dragon that guarded the Golden Fleece in the Voyage of the Argonauts. In the Middle Ages, tales of dragons seem to have become even more common. The #dragon in Europe, as a rule, was not conceived as having a humanoid form, and would not qualify as an instance of a #reptilian humanoid unless explicitly described as #humanoid.