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We had an awesome few days at @techcrunch #TCDisrupt SF 2018! ✨
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Thanks to all our amazing #NovartisHealthX challenge winners, finalists, our esteemed judges and the #HealthTech community! We’re so grateful and excited to play a role in shaping the future of healthcare together with you.
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#DisruptSF2018
#InnovateTogether
#NovartisBiome

Did you know that #multiplesclerosis can affect children and adolescents too? This disease impacts many areas of patients’ lives, such as going to school and playing sports. Erin started experiencing her first symptoms at the age of 15.

This week, the #NovartisBiome team is at @TechCrunch Disrupt SF 2018 and launching our inaugural #NovartisHealthX World Series Challenge – a global initiative with health tech innovators and entrepreneurs to partner with us to find creative new solutions to real-life healthcare challenges.
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Five finalists were selected from over 30 entries of digital solutions focused on solving challenges around heart failure. Come watch them pitch at the Novartis booth this afternoon at 12:45 pm.
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#disruptsf2018 #TCDisrupt #heathtech #whosgonnawin?

A #throwback to this year’s Community Partnership Day where our associates around the 🌍 volunteered to work with local organizations. Thanks to our associates & community partners for helping us continue this tradition of service! #NovartisCPD2018

During Migraine Awareness Week, we want to highlight the burden of migraine to reduce the stigma around this neurological disease. Shirley suffers from migraine but continues to work full time. She worked with her colleagues and employers to adapt her working environment to facilitate her productivity at work. We applaud women like Shirley. #MindfulofMigraine #stigma #patient #burden

When the gene that causes cystic fibrosis (CFTR) was discovered in 1989, scientists were optimistic that a cure was on the horizon. As years passed, hundreds of mutations were identified in the gene, but new treatments were slow to emerge, partly because scientists had trouble figuring out precisely where the gene is active. A multidisciplinary research team at the Novartis Institutes for BioMedical Research (NIBR) & @HarvardMed cataloged all the different cells in the airway, & the paths they take to become those cells. In the process, they discovered a completely new type of cell called a pulmonary ionocyte (pictured in pink). When the CFTR gene is active, it is usually in this new cell, which makes up just 1-2% of the airway. The team shared their discovery in @Nature.Research.

“Patient commitment is a responsibility – for us as a company and me as a scientist. By partnering with our patients, we are able to understand the unmet needs and integrate the patient perspective into our trial designs.” #HowWeSeeIt #WorkingWithPatients
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Sharareh Hosseinzadeh
Head of Clinical Patient Engagement
Novartis

A single-cell RNA sequencing platform developed at @HarvardMed makes it possible to catalog the gene activity of many cells. The seminal version of the platform processed more than 200 cells every 30 seconds and labeled their contents with unique barcodes. Using this technology, we were able to discover a new type of airway cell that may play a key role in cystic fibrosis, a genetic disease that damages the lungs and digestive system.

Continuous flow manufacturing is changing the way drugs are made, allowing chemists more creativity and flexibility. The technique flows small amounts of chemical ingredients through a streamlined process that operates without disruption, all the way from raw ingredient to tablet. The miniaturized technology opens up a realm of possible chemical combinations, which were prohibited because the chemical reactions required to make them were too volatile, wasteful, toxic or slow. With the continuous flow technique, potentially explosive reactions can be performed safely, as the amount of reaction material is small and can be monitored and controlled. This way chemists can be more creative with choices of reagents and reaction conditions. This technology, made possible by engineers and scientists at the Novartis-MIT (@MITpics) Center for Continuous Manufacturing (an alliance formed a decade ago) has the potential to reduce drug manufacturing time and manufacturing costs.

Scientists from Novartis & Icelandic Heart Association (IHA) recently discovered that the bloodstream contains multiple complex networks of proteins that act in concert to maintain health. And when these networks aren’t operating in perfect harmony, they also appear to be connected to the development of complex diseases, such as heart disease, diabetes, kidney disease, liver disease & more. These networks can’t be seen or heard in a physical exam. They aren’t traceable with a dye and they can’t be inferred by sequencing the genome. Rather, they only became evident when the research team leveraged big data — in this case, a complex and massive conglomeration of clinical, genomic and proteomic data about more than 5000 Icelanders, part of the Reykjavik Study (a research program launched in 1967 intended to get at the roots of heart disease and its prevention). The researchers’ analysis hinged on data gleaned from a single droplet of blood or serum from each Icelander. The data inside each droplet acted as a critical linker, connecting the dots between other volumes of data and suggesting that sometimes, the more complex the data, the more valuable. #datascience #reimaginemedicine

People with #migraine often feel misunderstood or judged. Kari explains how that can have a significant impact on her social life. #Stigma #Neurology

“Next to being a scientist, I am also a patient, suffering from a rare disease. I always had the wish to understand the disease and do something about it. Having a deep scientific expertise is one way to do this. The other way is to listen to patients and their needs.” #HowWeSeeIt #WorkingWithPatients
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Rocco Falchetto Director, Analytical Sciences & Imaging, NIBR
Novartis

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