Researchers from #France have uncovered what just might be one of the most overlooked causes of #Alzheimer disease and #dementia that most people have probably never even considered: Crop #chemicals.
A recent paper published in the Journal of Alzheimer’s Disease takes a closer look at this apparent connection, revealing that a class of #herbicides known as triazines appear to increase the body’s #production of two amyloid peptides associated with brain degeneration.
These peptides are known as Aβ42 and Aβ40, respectively, and Laurent Meijer from ManRos Therapeutics in Roscoff, France, says they’re part of what’s known as the “human chemical exposome,” or HCE – a grouping of more than 85,000 chemical compounds that are known to #damage human #health .
Using a cell model, Meijer and his colleagues screened various HCE libraries to identify any Aβ42 inducers that might be linked to Alzheimer’s. Of the more than 3,500 compounds they tested, six triazine herbicides were identified as directly spurring the production of extracellular Aβ42.
Upon analyzing these compounds using immunoprecipitation and mass spectrometry, the team observed enhanced production of Aβ peptides cleaved at positions 42/43, as well as reduced production of peptides cleaved at positions 38 and lower – both characteristics of onset Alzheimer’s disease and dementia.
The six triazines were also found to affect various other cleavage patterns within the peptide matrix that are further linked to causing dementia. Based on these and other observations, Meijer and his colleagues concluded that triazines: “… [E]nhance the production of toxic, aggregation prone Aβ42/Aβ43 amyloids, suggesting the possible existence of environmental ‘Alzheimerogens’ (by analogy with carcinogens) which may contribute to the initiation and propagation of the amyloidogenic process in late-onset AD.” #people #corporate #greedovercompassion #wakeup #inhumane